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Fibromyalgia syndrome (FMS) is characterised by chronic widespread muscle pain, stiffness, and tenderness to palpation at specific tender points as well as associated sleep disorder, fatigue, and cognitive dysfunction. Diagnostic criteria include pain that is perceived for at least three months all over the body, but particularly at the tender points. FMS is a common disease which affects at least 2% of the population with a much higher prevalence in women than in men. The causes of fibromyalgia are unknown. However, evidence for central pain processing abnormalities in FMS patients continues to increase.
There are currently no medications approved for the treatment of the signs and symptoms of FMS. However, various analgesics, antidepressants, muscle relaxants or anti-epileptic drugs are being used. These medications frequently are of limited efficacy and are associated with considerable side effects.